The Spanish in the Americas: Northern Expansion
Like with every empire, the early conquistadors of the Spanish Empire wanted to expand their holds in the New World, especially in pursuit of rumors of El Dorado, the City of Gold, of which they heard about from the natives which reside in what is now the country of Columbia. However, all of the explorations from such conquistadors/explorers as Cabeza de Vaca, Hernan de Soto, and Coronado for such a city came up empty-handed and this created a fifty-year period of indifference.
By the 1590s, about a hundred years after Columbus ventured to the New World. merchants and mine owners wanted to develop trade, the Crown wanted to secure the northern border to protect valuable mines, and the Church wanted to spread Christianity.
Although the term wouldn't be coined until 1845 by John L. O'Sullivan, this was a perfect example of "Manifest Destiny". "Manifest Destiny" is the spreading of your influence as far north, south, east, and west as possible. We'll get to more examples of "Manifest Destiny" as we go further in time.